Cholesterol uptake into heart and skeletal muscle of lipoprotein lipase transgenic mice: Evidence that statin therapy increases muscle lipid uptake
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چکیده
transgenic mice: Evidence that statin therapy increases muscle lipid uptake Masayoshi Yokoyama, Toru Seo, Taesik Park, Hiroaki Yagyu, Yunying Hu, Ni Huiping Son, Ayanna S. Augustus, Reeba K. Vikramadithyan, Rajasekhar Ramakrishnan, Leslie K. Pulawa, Robert H. Eckel, Ira J. Goldberg Department of Medicine, Columbia University, New York, NY 10032, and Department of Pediatrics and Institute of Human Nutrition, Columbia University, New York, NY 10032, and Department of Medicine and Center for Human Nutrition, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045. Department of Medicine Columbia University 630 West 168th Street New York, NY 10032 Phone: 212 305-5961 FAX: 212 305-5384 Email: [email protected]
منابع مشابه
Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle.
Regulation of cholesterol metabolism in cultured cells and in the liver is dependent on actions of the LDL receptor. However, nonhepatic tissues have multiple pathways of cholesterol uptake. One possible pathway is mediated by LPL, an enzyme that primarily hydrolyzes plasma triglyceride into fatty acids. In this study, LDL uptake and tissue cholesterol levels in heart and skeletal muscle of wil...
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تاریخ انتشار 2006